Impairment of the Endothelium and Disorder of Microcirculation in Humans and Animals Exposed to Infrasound due to Irregular Mechano-Transduction

The microcirculation of mammals is an autoregulated and complex synchronised system according to the current demand for nutrients oxygen. undisturbed course vital functions such as growth, blood pressure regulation, inflammatory sequence embryogenesis bound endothelial integrity. sensible vasomotion particularly dependent on it. Mechano-transduction signalling networks play a critical role in cellular processes are decisive physiological mechanism adequate NO-release, main responsible autoregulation vessels. Disturbed integrity, originating, e.g., from chronic oxidative stress and/or mechanic (oscillatory) stress, leads disturbance well disequilibrium redox systems, recognized cause development inflammation diseases atherosclerosis corresponding secondary illnesses, possibly cancer. cytoskeleton, which corresponds viscoelastic “tensegrity model”, offers possibility mechano-transduction via its special construction. rapidly growing knowledge about mechanical forces sensing regulation last years (that culminated Nobel Prize award decoding pressure/vibration ion channels), led us following hypothesis: extern stressor “Noise” produces under certain conditions oscillatory field physiologically laminar flow bed capillaries, able lead irregular mechano-transductions. Findings provide strict dependence frequency with determination thresholds 1:1 transmission. knowledge, recently gained mechano-transduction, sheds new light importance low frequencies. This could indicate long-sought pathophysiological way infrasound can exert effect at level. Noise-exposed citizens, who live near infrastructures biogas installation, heat pumps, block-type thermal power stations bigger industrial wind turbines (IWT’s), show worldwide mainly symptomatology associated microcirculatory disorder. Conceivable also effects insects or fishes, since piezo-channels recognised conserved structures all multicellular organism. An experimental design proposed demonstrate direct pathological influence defined strength, frequency, effect/time profile duration sensitive vasomotion.